Structures of human PRC2 with its cofactors AEBP2 and JARID2 | Zendy

Vignesh Kasinath | Zendy; Marco Faini | Zendy; Simon Poepsel | Zendy; Dvir Reif | Zendy; Xinyu A. Feng | Zendy; Goran Stjepanović | Zendy; Ruedi Aebersold | Zendy; Eva Nogales | Zendy

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Structures of human PRC2 with its cofactors AEBP2 and JARID2

Author(s) -

Vignesh Kasinath,

Marco Faini,

Simon Poepsel,

Dvir Reif,

Xinyu A. Feng,

Goran Stjepanović,

Ruedi Aebersold,

Eva Nogales

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aar5700

Subject(s) - prc2 , histone h3 , histone , microbiology and biotechnology , biology , chemistry , computational biology , genetics , gene

Complete architecture of PRC2 Polycomb repressive complex 2 (PRC2) methylates lysine 27 in histone H3 to achieve gene silencing. Kasinathet al. report multiple structures of complete human PRC2 with its four core subunits (EZH2, EED, SUZ12, and RBAP48) and two cofactors (AEBP2 and JARID2) in different active states. These structures describe the molecular mimicry of H3 tails by AEBP2 and JARID2 to regulate PRC2 activity and reveal the organizational role of SUZ12 in maintaining the integrity and stability of the complex.Science , this issue p.940

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