An evolutionary perspective on immunometabolism | Zendy

Andrew Wang | Zendy; Harding H. Luan | Zendy; Ruslan Medzhitov | Zendy

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An evolutionary perspective on immunometabolism

Author(s) -

Andrew Wang,

Harding H. Luan,

Ruslan Medzhitov

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aar3932

Subject(s) - energy metabolism , immune system , perspective (graphical) , biology , cell metabolism , immunity , disease , neuroscience , metabolism , immunology , medicine , computer science , endocrinology , artificial intelligence , pathology

Metabolism as a driver of immune response All living organisms need energy and metabolic building blocks to sustain biological processes. Wanget al. review immunometabolism, applying the principles of life history theory. They highlight recent advances showing the reciprocal interactions between systemic metabolism and immunity, as well as how inflammation can alter the functional state of metabolic organs and their central control by the hypothalamus. Such coordinated cross-talk between whole-body and immune cell metabolism is involved in a variety of health and disease states.Science , this issue p.eaar3932

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