Co-regulatory networks of human serum proteins link genetics to disease | Zendy

Valur Emilsson | Zendy; Marjan Ilkov | Zendy; John R. Lamb | Zendy; Nancy Finkel | Zendy; Elías F. Guðmundsson | Zendy; Rebecca Pitts | Zendy; Heather Hoover | Zendy; Valborg Guðmundsdóttir | Zendy; Shane R. Horman | Zendy; Thor Aspelund | Zendy; Le Shu | Zendy; Vladimir Trifonov | Zendy; Sigurður Sigurðsson | Zendy; Andrei Manolescu | Zendy; Jun Zhu | Zendy; Ö Ólafsson | Zendy; Jóhanna Jakobsdóttir | Zendy; Scott A. Lesley | Zendy; Jeremy To | Zendy; Jia Zhang | Zendy; Tamara B. Harris | Zendy; Lenore J. Launer | Zendy; Bin Zhang | Zendy; Guðný Eiríksdóttir | Zendy; Xia Yang | Zendy; Anthony P. Orth | Zendy; Lori L. Jennings | Zendy; Vilmundur Guðnason | Zendy

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Co-regulatory networks of human serum proteins link genetics to disease

Author(s) -

Valur Emilsson,

Marjan Ilkov,

John R. Lamb,

Nancy Finkel,

Elías F. Guðmundsson,

Rebecca Pitts,

Heather Hoover,

Valborg Guðmundsdóttir,

Shane R. Horman,

Thor Aspelund,

Le Shu,

Vladimir Trifonov,

Sigurður Sigurðsson,

Andrei Manolescu,

Jun Zhu,

Ö Ólafsson,

Jóhanna Jakobsdóttir,

Scott A. Lesley,

Jeremy To,

Jia Zhang,

Tamara B. Harris,

Lenore J. Launer,

Bin Zhang,

Guðný Eiríksdóttir,

Xia Yang,

Anthony P. Orth,

Lori L. Jennings,

Vilmundur Guðnason

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaq1327

Subject(s) - proteome , disease , biology , human blood , blood proteins , genetics , function (biology) , computational biology , human genetics , gene , medicine , physiology , endocrinology

The blood proteome in disease Understanding the function of human blood serum proteins in disease has been limited by difficulties in monitoring their production, accumulation, and distribution. Emilssonet al. investigated human serum proteins of more than 5000 Icelanders over the age of 65. The composition of blood serum includes a complex regulatory network of proteins that are globally coordinated across most or all tissues. The authors identified modules and functional groups associated with disease and health outcomes and were able to link genetic variants to complex diseases.Science , this issue p.769

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