Open AccessSpatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
Author(s) -
Tomasz J. Nowakowski,
Aparna Bhaduri,
Alex A. Pollen,
Beatriz Alvarado,
Mohammed A. Mostajo-Radji,
Elizabeth Di Lullo,
Maximilian Haeussler,
Carmen Sandoval-Espinosa,
Siyuan Liu,
Dmitry Velmeshev,
Johain R. Ounadjela,
Joe Shuga,
Xiaohui Wang,
Daniel A. Lim,
Jay West,
Anne Leyrat,
W. James Kent,
Arnold R. Kriegstein
Publication year - 2017
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.aap8809
Subject(s) - cerebrum , biology , neuroscience , neurogenesis , cell type , transcription factor , cerebral cortex , cortex (anatomy) , human brain , developmental biology , organogenesis , gene expression , gene , cell , microbiology and biotechnology , central nervous system , genetics
Building a brain The human brain is built in an inside-out manner as a series of layers. Although progenitor cells spin off new neurons in a seemingly organized fashion, the devil is in the details. Nowakowskiet al. analyzed the transcriptomes of single cells from the developing brain to elucidate the hidden complexity of brain construction. For each cell, its position within the brain matters, as well as what type of neuron is being made at what point during overall development. These individual expression patterns result in organized diversity in the brain's cortex.Science , this issue p.1318
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