The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes | Zendy

Donglei Zhang | Zendy; Shikui Tu | Zendy; Michael W. Stubna | Zendy; Wei-Sheng Wu | Zendy; Wei-Che Huang | Zendy; Zhiping Weng | Zendy; Heng-Chi Lee | Zendy

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The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes

Author(s) -

Donglei Zhang,

Shikui Tu,

Michael W. Stubna,

Wei-Sheng Wu,

Wei-Che Huang,

Zhiping Weng,

Heng-Chi Lee

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aao2840

Subject(s) - piwi interacting rna , endogeny , gene silencing , gene , biology , genetics , resistance (ecology) , computational biology , transposable element , genome , ecology , biochemistry

Self-defense by avoiding self-targeting By silencing transposons, Piwi-interacting RNAs (piRNAs) protect the stability of animal genomes in germ lines. However, many piRNAs do not map to transposons, and their functions have remained undefined. Zhanget al. described the piRNA targeting logic inCaenorhabditis elegans and identified an intrinsic sequence signal in endogenous germline genes that confer resistance to piRNA silencing. Thus, diverse piRNAs silence foreign nucleic acids but spare self genes to defend theC. elegans genome. In addition, multiple foreign transgenes can be engineered to escape piRNA targeting, allowing successful expression in the germline.Science , this issue p.587

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