Systematic analysis of complex genetic interactions | Zendy

Elena Kuzmin | Zendy; Benjamin VanderSluis | Zendy; Wen Wang | Zendy; Guihong Tan | Zendy; Raamesh Deshpande | Zendy; Yiqun Chen | Zendy; Matej Ušaj | Zendy; Attila Balint | Zendy; Mojca Mattiazzi Ušaj | Zendy; Jolanda van Leeuwen | Zendy; Elizabeth N. Koch | Zendy; Carles Pons | Zendy; Andrius J. Dagilis | Zendy; Michael Pryszlak | Zendy; Jason Zi Yang Wang | Zendy; Julia Hanchard | Zendy; Margot Riggi | Zendy; Kaicong Xu | Zendy; Hamed Heydari | Zendy; Bryan-Joseph San Luis | Zendy; Ermira Shuteriqi | Zendy; Hongwei Zhu | Zendy; Nydia van Dyk | Zendy; Sara Sharifpoor | Zendy; Michael Costanzo | Zendy; Robbie Loewith | Zendy; Amy A. Caudy | Zendy; Daniel I. Bolnick | Zendy; Grant W. Brown | Zendy; Brenda Andrews | Zendy; Charles Boone | Zendy; Chad L. Myers | Zendy

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Systematic analysis of complex genetic interactions

Author(s) -

Elena Kuzmin,

Benjamin VanderSluis,

Wen Wang,

Guihong Tan,

Raamesh Deshpande,

Yiqun Chen,

Matej Ušaj,

Attila Balint,

Mojca Mattiazzi Ušaj,

Jolanda van Leeuwen,

Elizabeth N. Koch,

Carles Pons,

Andrius J. Dagilis,

Michael Pryszlak,

Jason Zi Yang Wang,

Julia Hanchard,

Margot Riggi,

Kaicong Xu,

Hamed Heydari,

Bryan-Joseph San Luis,

Ermira Shuteriqi,

Hongwei Zhu,

Nydia van Dyk,

Sara Sharifpoor,

Michael Costanzo,

Robbie Loewith,

Amy A. Caudy,

Daniel I. Bolnick,

Grant W. Brown,

Brenda Andrews,

Charles Boone,

Chad L. Myers

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aao1729

Subject(s) - biology , genetics , gene , inheritance (genetic algorithm) , mutant , phenotype , epistasis , gene interaction , genetic analysis , mutation , interaction network , computational biology

To systematically explore complex genetic interactions, we constructed ~200,000 yeast triple mutants and scored negative trigenic interactions. We selected double-mutant query genes across a broad spectrum of biological processes, spanning a range of quantitative features of the global digenic interaction network and tested for a genetic interaction with a third mutation. Trigenic interactions often occurred among functionally related genes, and essential genes were hubs on the trigenic network. Despite their functional enrichment, trigenic interactions tended to link genes in distant bioprocesses and displayed a weaker magnitude than digenic interactions. We estimate that the global trigenic interaction network is ~100 times as large as the global digenic network, highlighting the potential for complex genetic interactions to affect the biology of inheritance, including the genotype-to-phenotype relationship.

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