CX3CR1 + mononuclear phagocytes control immunity to intestinal fungi | Zendy

Irina Leonardi | Zendy; Xin Li | Zendy; Alexa Semon | Zendy; Dalin Li | Zendy; Itai Doron | Zendy; Gregory Putzel | Zendy; Agnieszka S. Bar | Zendy; Daniel Prieto | Zendy; María Rescigno | Zendy; Dermot McGovern | Zendy; Jesús Plá | Zendy; Iliyan D. Iliev | Zendy

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CX3CR1 ⁺ mononuclear phagocytes control immunity to intestinal fungi

Author(s) -

Irina Leonardi,

Xin Li,

Alexa Semon,

Dalin Li,

Itai Doron,

Gregory Putzel,

Agnieszka S. Bar,

Daniel Prieto,

María Rescigno,

Dermot McGovern,

Jesús Plá,

Iliyan D. Iliev

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aao1503

Subject(s) - mycobiota , cx3cr1 , biology , immunity , immune system , microbiology and biotechnology , innate immune system , posaconazole , immunology , acquired immune system , antifungal , chemokine , chemokine receptor , amphotericin b , ecology

Phagocytes patrol intestinal fungi Maintaining a healthy balance of gut bacteria can promote good health. Leonardiet al. show that fungi can also interact with gut immune cells to maintain intestinal well-being. CX3CR1+ mononuclear phagocytes (MNPs) patrol the intestine and promote antifungal immunity. Genetic deletion of CX3CR1 in MNPs caused colitis-like symptoms in mice. CX3CR1 polymorphisms were detected in Crohn's disease patients that were unable to produce antibodies against multiple fungal species. Thus, commensal fungi may be as important as bacteria in maintaining gut health, and antifungal therapy could hold promise for treating intestinal inflammation.Science , this issue p.232

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