Open AccessPerivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles
Author(s) -
Hae Woong Choi,
Jutamas Suwanpradid,
Il Hwan Kim,
Herman F. Staats,
Muzlifah Haniffa,
Amanda S. MacLeod,
Soman N. Abraham
Publication year - 2018
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.aao0666
Subject(s) - microvesicles , anaphylaxis , mast (botany) , immunology , allergy , mast cell , chemistry , microbiology and biotechnology , medicine , biology , microrna , biochemistry , gene
Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b + perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and trigger anaphylaxis. DC antigen transfer involves the active discharge of surface-associated antigens on 0.5- to 1.0-micrometer microvesicles (MVs) generated by vacuolar protein sorting 4 (VPS4). Antigen sharing by DCs is not limited to MCs, as neighboring DCs also acquire antigen-bearing MVs. This capacity of DCs to distribute antigen-bearing MVs to various immune cells in the perivascular space potentiates inflammatory and immune responses to blood-borne antigens.
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