Ruthenium-catalyzed insertion of adjacent diol carbon atoms into C-C bonds: Entry to type II polyketides | Zendy

Matthias Bender | Zendy; Ben W. H. Turnbull | Zendy; Brett R. Ambler | Zendy; Michael J. Krische | Zendy

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Ruthenium-catalyzed insertion of adjacent diol carbon atoms into C-C bonds: Entry to type II polyketides

Author(s) -

Matthias Bender,

Ben W. H. Turnbull,

Brett R. Ambler,

Michael J. Krische

Publication year - 2017

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aao0453

Subject(s) - ruthenium , catalysis , chemistry , cleave , dehydrogenation , stereochemistry , polymer chemistry , organic chemistry , enzyme

Current catalytic processes involving carbon-carbon bond activation rely on π-unsaturated coupling partners. Exploiting the concept of transfer hydrogenative coupling, we report a ruthenium(0)-catalyzed cycloaddition of benzocyclobutenones that functionalizes two adjacent saturated diol carbon-hydrogen bonds. These regio- and diastereoselective processes enable convergent construction of type II polyketide substructures.

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