Open AccessThe microbial metabolite desaminotyrosine protects from influenza through type I interferon
Author(s) -
Ashley L. Steed,
George P. Christophi,
Gerard E. Kaiko,
Lulu Sun,
Victoria M. Goodwin,
Umang Jain,
Ekaterina Esaulova,
Maxim N. Artyomov,
David J. Morales,
Michael J. Holtzman,
Adrianus C. M. Boon,
Deborah J. Lenschow,
Thaddeus S. Stappenbeck
Publication year - 2017
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.aam5336
Subject(s) - interferon , biology , microbiology and biotechnology , metabolite , priming (agriculture) , influenza a virus , immunology , gut flora , immune system , interferon type i , wild type , virology , virus , gene , mutant , genetics , biochemistry , botany , germination
Eat more plants for influenza resilience Antibiotic treatment worsens influenza in mice, possibly because the concomitant loss of the microbiota interrupts the production of bioactive metabolites. Steedet al. found that a microbial product, desaminotyrosine (DAT), produced by an obligate clostridial anaerobe from the digestion of plant flavonoids, is beneficial during influenza. DAT enters the bloodstream and triggers type I interferon signaling, which then augments antiviral responses by phagocytic cells. Without DAT, influenza virus causes inflammation and severe disease.Science , this issue p.498
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