Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer | Zendy

Susan Bullman | Zendy; Chandra Sekhar Pedamallu | Zendy; Ewa Sicińska | Zendy; Thomas E. Clancy | Zendy; Xiaoyang Zhang | Zendy; Diana Cai | Zendy; Doneuberg | Zendy; Katherine Huang | Zendy; Fatima Guevara | Zendy; Timothy Nelson | Zendy; Otari Chipashvili | Zendy; Timothy Hagan | Zendy; Mark Walker | Zendy; Aruna Ramachandran | Zendy; Begoña Diosdado | Zendy; Garazi Serna | Zendy; Nuria Mulet | Zendy; Stefania Landolfi | Zendy; Santiago Ramón y Cajal | Zendy; Roberta Fasani | Zendy; Andrew J. Aguirre | Zendy; Kimmie Ng | Zendy; Elena Élez | Zendy; Shuji Ogino | Zendy; Josep Tabernero | Zendy; Charles S. Fuchs | Zendy; William C. Hahn | Zendy; Paolo Nucíforo | Zendy; Matthew Meyerson | Zendy

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Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer

Author(s) -

Susan Bullman,

Chandra Sekhar Pedamallu,

Ewa Sicińska,

Thomas E. Clancy,

Xiaoyang Zhang,

Diana Cai,

Doneuberg,

Katherine Huang,

Fatima Guevara,

Timothy Nelson,

Otari Chipashvili,

Timothy Hagan,

Mark Walker,

Aruna Ramachandran,

Begoña Diosdado,

Garazi Serna,

Nuria Mulet,

Stefania Landolfi,

Santiago Ramón y Cajal,

Roberta Fasani,

Andrew J. Aguirre,

Kimmie Ng,

Elena Élez,

Shuji Ogino,

Josep Tabernero,

Charles S. Fuchs,

William C. Hahn,

Paolo Nucíforo,

Matthew Meyerson

Publication year - 2017

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aal5240

Subject(s) - fusobacterium nucleatum , colorectal cancer , carcinogenesis , bacteria , fusobacterium , cancer , stroma , biology , antibiotics , microbiology and biotechnology , cancer research , immunology , genetics , porphyromonas gingivalis , bacteroides , immunohistochemistry

Bacteria go the distance in cancer The bacterial speciesFusobacterium nucleatum is associated with a subset of human colorectal cancers, but its role in tumorigenesis is unclear. Studying patient samples, Bullmanet al. found thatF. nucleatum and certain co-occurring bacteria were present not only in primary tumors but also in distant metastases. Preliminary evidence suggests that the bacterium is localized primarily within the metastatic cancer cells rather than in the stroma. Antibiotic treatment of mice carrying xenografts ofF. nucleatum –positive human colorectal cancer slowed tumor growth, consistent with a causal role for the bacterium in tumorigenesis.Science , this issue p.1443

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