Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells | Zendy

Chen Zhao | Zendy; Shang Cai | Zendy; Kunyoo Shin | Zendy; Agnes Lim | Zendy; Tomer Kalisky | Zendy; Wan-Jin Lu | Zendy; Michael F. Clarke | Zendy; Philip A. Beachy | Zendy

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Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells

Author(s) -

Chen Zhao,

Shang Cai,

Kunyoo Shin,

Agnes Lim,

Tomer Kalisky,

Wan-Jin Lu,

Michael F. Clarke,

Philip A. Beachy

Publication year - 2017

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aal3485

Subject(s) - stem cell , biology , stromal cell , microbiology and biotechnology , cancer research , hedgehog , hormone , hedgehog signaling pathway , signal transduction , endocrinology , medicine

Double duty for mammary stem cell niche The stem cell niche is a complex local signaling microenvironment that regulates stem cell activity for tissue and organ maintenance and regeneration. As well as responding locally, during puberty, the mammary gland stem cell niche also responds to systemic hormonal signals. Zhaoet al. have found that Gli2, a transcriptional effector of Hedgehog signaling, coordinates the niche-signaling program and activates expression of receptors for the mammatrophic hormones estrogen and growth hormone throughout the mammary gland (see the Perspective by Robertson). Disease may result not only from stem cell defects, but also from dysregulation of the microenvironment.Science , this issue p.eaal3485 ; see also p.250

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