Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver | Zendy

Carlos M. Minutti | Zendy; Lucy H. JacksonJones | Zendy; Belén García-Fojeda | Zendy; Johanna A. Knipper | Zendy; Tara E. Sutherland | Zendy; Nicola Logan | Zendy; Emma Ringqvist | Zendy; Raquel GuillamatPrats | Zendy; David A. Ferenbach | Zendy; Antonio Artigas | Zendy; Cordula Stamme | Zendy; Zissis C. Chroneos | Zendy; Dietmar M. Zaiss | Zendy; Cristina Casals | Zendy; Judith E. Allen | Zendy

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Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

Author(s) -

Carlos M. Minutti,

Lucy H. JacksonJones,

Belén García-Fojeda,

Johanna A. Knipper,

Tara E. Sutherland,

Nicola Logan,

Emma Ringqvist,

Raquel GuillamatPrats,

David A. Ferenbach,

Antonio Artigas,

Cordula Stamme,

Zissis C. Chroneos,

Dietmar M. Zaiss,

Cristina Casals,

Judith E. Allen

Publication year - 2017

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaj2067

Subject(s) - lung , inflammation , macrophage , alveolar macrophage , fibrosis , immunology , complement system , biology , pathology , medicine , immune system , biochemistry , in vitro

Local macrophage clean-up Infection, especially by helminths or bacteria, can cause tissue damage (see the Perspective by Bouchery and Harris). Minuttiet al. studied mouse models of helminth infection and fibrosis. They expressed surfactant protein A (a member of the complement component C1q family) in the lung, which enhanced interleukin-4 (IL-4)-mediated proliferation and activation of alveolar macrophages. This activation accelerated helminth clearance and reduced lung injury. In the peritoneum, C1q boosted macrophage activation for liver repair after bacterial infection. By a different approach, Bosurgiet al. discovered that after wounding caused by migrating helminths in the lung or during inflammation in the gut of mice, IL-4 and IL-13 act only in the presence of apoptotic cells to promote tissue repair by local macrophages.Science , this issue p.1076 , p.1072 ; see also p.1014

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