Rapid development of a DNA vaccine for Zika virus | Zendy

Kimberly A. Dowd | Zendy; SungYoul Ko | Zendy; Kaitlyn M. Morabito | Zendy; Eun Sung Yang | Zendy; Rebecca S. Pelc | Zendy; Christina R. DeMaso | Zendy; Leda R. Castilho | Zendy; Peter Abbink | Zendy; Michael Boyd | Zendy; Ramya Nityanandam | Zendy; David Gordon | Zendy; John R. Gallagher | Zendy; Xuejun Chen | Zendy; John-Paul Todd | Zendy; Yaroslav Tsybovsky | Zendy; Audray K. Harris | Zendy; YanJang S. Huang | Zendy; Stephen Higgs | Zendy; Dana L. Vanlandingham | Zendy; Hanné Andersen | Zendy; Mark G. Lewis | Zendy; Rafael De La Barrera | Zendy; Kenneth H. Eckels | Zendy; Richard G. Jarman | Zendy; Martha Nason | Zendy; Dan H. Barouch | Zendy; Mario Roederer | Zendy; WingPui Kong | Zendy; John R. Mascola | Zendy; Theodore C. Pierson | Zendy; Barney S. Graham | Zendy

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Rapid development of a DNA vaccine for Zika virus

Author(s) -

Kimberly A. Dowd,

SungYoul Ko,

Kaitlyn M. Morabito,

Eun Sung Yang,

Rebecca S. Pelc,

Christina R. DeMaso,

Leda R. Castilho,

Peter Abbink,

Michael Boyd,

Ramya Nityanandam,

David Gordon,

John R. Gallagher,

Xuejun Chen,

John-Paul Todd,

Yaroslav Tsybovsky,

Audray K. Harris,

YanJang S. Huang,

Stephen Higgs,

Dana L. Vanlandingham,

Hanné Andersen,

Mark G. Lewis,

Rafael De La Barrera,

Kenneth H. Eckels,

Richard G. Jarman,

Martha Nason,

Dan H. Barouch,

Mario Roederer,

WingPui Kong,

John R. Mascola,

Theodore C. Pierson,

Barney S. Graham

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aai9137

Subject(s) - zika virus , virology , dna vaccination , biology , neutralizing antibody , virus , medicine , antibody , immunization , immunology

Zika virus (ZIKV) was identified as a cause of congenital disease during the explosive outbreak in the Americas and Caribbean that began in 2015. Because of the ongoing fetal risk from endemic disease and travel-related exposures, a vaccine to prevent viremia in women of childbearing age and their partners is imperative. We found that vaccination with DNA expressing the premembrane and envelope proteins of ZIKV was immunogenic in mice and nonhuman primates, and protection against viremia after ZIKV challenge correlated with serum neutralizing activity. These data not only indicate that DNA vaccination could be a successful approach to protect against ZIKV infection, but also suggest a protective threshold of vaccine-induced neutralizing activity that prevents viremia after acute infection.

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