Bifurcating electron-transfer pathways in DNA photolyases determine the repair quantum yield | Zendy

Meng Zhang | Zendy; Lijuan Wang | Zendy; Shi Shu | Zendy; Aziz Sancar | Zendy; Dongping Zhong | Zendy

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Bifurcating electron-transfer pathways in DNA photolyases determine the repair quantum yield

Author(s) -

Meng Zhang,

Lijuan Wang,

Shi Shu,

Aziz Sancar,

Dongping Zhong

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aah6071

Subject(s) - photolyase , pyrimidine dimer , flavin group , electron transfer , quantum yield , cofactor , dna , chemistry , electron transport chain , photochemistry , dna repair , yield (engineering) , biophysics , enzyme , biochemistry , biology , materials science , physics , fluorescence , optics , metallurgy

Two roads diverged in a yellow photolyase Photolyase enzymes repair DNA that has been damaged by ultraviolet sunlight. The repair process begins when blue light absorption by a cofactor drives an electron transfer step. Zhanget al. applied ultrafast absorption spectroscopy to study the dynamics of this step. A bifurcation in the electron transfer pathway favors a direct tunneling mechanism in the prokaryotic enzymes and a two-step hopping mechanism in the eukaryotic variety. This difference explains the higher repair quantum yield seen in prokaryotes.Science , this issue p.209

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