Metal-catalyzed reductive coupling of olefin-derived nucleophiles: Reinventing carbonyl addition | Zendy

Khoa Diệu Vân Nguyễn | Zendy; Boyoung Y. Park | Zendy; Tom Luong | Zendy; Hiroki Sato | Zendy; Victoria J. Garza | Zendy; Michael J. Krische | Zendy

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Metal-catalyzed reductive coupling of olefin-derived nucleophiles: Reinventing carbonyl addition

Author(s) -

Khoa Diệu Vân Nguyễn,

Boyoung Y. Park,

Tom Luong,

Hiroki Sato,

Victoria J. Garza,

Michael J. Krische

Publication year - 2016

Publication title -

science

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aah5133

Subject(s) - nucleophile , olefin fiber , chemistry , catalysis , reagent , alcohol , halide , organic chemistry , coupling reaction , grignard reagent , medicinal chemistry

α-Olefins are the most abundant petrochemical feedstock beyond alkanes, yet their use in commodity chemical manufacture is largely focused on polymerization and hydroformylation. The development of byproduct-free catalytic C-C bond-forming reactions that convert olefins to value-added products remains an important objective. Here, we review catalytic intermolecular reductive couplings of unactivated and activated olefin-derived nucleophiles with carbonyl partners. These processes represent an alternative to the longstanding use of stoichiometric organometallic reagents in carbonyl addition.

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