Selective modulation of cortical state during spatial attention | Zendy

Tatiana A. Engel | Zendy; Nicholas A. Steinmetz | Zendy; Marc Alwin Gieselmann | Zendy; Alexander Thiele | Zendy; Tirin Moore | Zendy; Kwabena Boahen | Zendy

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Selective modulation of cortical state during spatial attention

Author(s) -

Tatiana A. Engel,

Nicholas A. Steinmetz,

Marc Alwin Gieselmann,

Alexander Thiele,

Tirin Moore,

Kwabena Boahen

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aag1420

Subject(s) - neuroscience , cortical neurons , visual cortex , modulation (music) , affect (linguistics) , cortex (anatomy) , neural activity , spatial modulation , inhibitory postsynaptic potential , psychology , biology , physics , computer science , communication , channel (broadcasting) , mimo , acoustics , computer network

Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.

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