Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus | Zendy

Jinyan Liu | Zendy; Khader Ghneim | Zendy; Devin Sok | Zendy; William J. Bosche | Zendy; Yuan Li | Zendy; Elizabeth Chipriano | Zendy; Brian Berkemeier | Zendy; Kelli Oswald | Zendy; Erica N. Borducchi | Zendy; Crystal Cabral | Zendy; Lauren Peter | Zendy; Amanda Brinkman | Zendy; Mayuri Shetty | Zendy; Jessica C. Jimenez | Zendy; Jade Mondesir | Zendy; Benjamin Lee | Zendy; Patricia Giglio | Zendy; Abishek Chandrashekar | Zendy; Peter Abbink | Zendy; Arnaud D. Colantonio | Zendy; Courtney Gittens | Zendy; Chantelle Baker | Zendy; Wendeline Wagner | Zendy; Mark G. Lewis | Zendy; Wenjun Li | Zendy; RafickPierre Sékaly | Zendy; Jeffrey D. Lifson | Zendy; Dennis R. Burton | Zendy; Dan H. Barouch | Zendy

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Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

Author(s) -

Jinyan Liu,

Khader Ghneim,

Devin Sok,

William J. Bosche,

Yuan Li,

Elizabeth Chipriano,

Brian Berkemeier,

Kelli Oswald,

Erica N. Borducchi,

Crystal Cabral,

Lauren Peter,

Amanda Brinkman,

Mayuri Shetty,

Jessica C. Jimenez,

Jade Mondesir,

Benjamin Lee,

Patricia Giglio,

Abishek Chandrashekar,

Peter Abbink,

Arnaud D. Colantonio,

Courtney Gittens,

Chantelle Baker,

Wendeline Wagner,

Mark G. Lewis,

Wenjun Li,

RafickPierre Sékaly,

Jeffrey D. Lifson,

Dennis R. Burton,

Dan H. Barouch

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aag0491

Subject(s) - virology , virus , antibody , biology , innate immune system , simian immunodeficiency virus , immune system , immunology , adoptive cell transfer , neutralizing antibody , rna , t cell , gene , biochemistry

HIV-1–specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We administered a fully protective dose of the bNAb PGT121 to rhesus monkeys and challenged them intravaginally with SHIV-SF162P3. In PGT121-treated animals, we detected low levels of viral RNA and viral DNA in distal tissues for seven days following challenge. Viral RNA–positive tissues showed transcriptomic changes indicative of innate immune activation, and cells from these tissues initiated infection after adoptive transfer into naïve hosts. These data demonstrate that bNAb-mediated protection against a mucosal virus challenge can involve clearance of infectious virus in distal tissues.

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