Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation | Zendy

Bryan A. Gibson | Zendy; Yajie Zhang | Zendy; Hong Jiang | Zendy; Kristine M. Hussey | Zendy; Jonathan H. Shrimp | Zendy; Hening Lin | Zendy; Frank Schwede | Zendy; Yonghao Yu | Zendy; W. Lee Kraus | Zendy

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Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

Author(s) -

Bryan A. Gibson,

Yajie Zhang,

Hong Jiang,

Kristine M. Hussey,

Jonathan H. Shrimp,

Hening Lin,

Frank Schwede,

Yonghao Yu,

W. Lee Kraus

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaf7865

Subject(s) - nad+ kinase , poly adp ribose polymerase , adp ribosylation , nicotinamide adenine dinucleotide , polymerase , rna polymerase ii , biology , proteome , biochemistry , chemistry , microbiology and biotechnology , enzyme , promoter , gene expression , gene

Mapping ADP-ribosylation by PARPs During many cell processes, ADP-ribose is transferred from NAD+ onto protein substrates by poly(ADP-ribose) polymerases (PARPs). Gibsonet al. developed a method to track ribose transfer events and mapped hundreds of sites of ADP-ribosylation for PARPs 1, 2, and 3 across the proteome and genome. One PARP-1 target is NELF, a protein complex that regulates pausing by RNA polymerase II. If NELF is ribosylated, pausing is released and productive transcription elongation resumes.Science , this issue p.45

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