Imprinting and recalling cortical ensembles | Zendy

Luis CarrilloReid | Zendy; Weijian Yang | Zendy; Yuki Bando | Zendy; Darcy S. Peterka | Zendy; Rafael Yuste | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Imprinting and recalling cortical ensembles

Author(s) -

Luis CarrilloReid,

Weijian Yang,

Yuki Bando,

Darcy S. Peterka,

Rafael Yuste

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaf7560

Subject(s) - optogenetics , neuroscience , hebbian theory , biological neural network , neuroplasticity , cortical neurons , visual cortex , premovement neuronal activity , imprinting (psychology) , neuronal circuits , nerve net , cortex (anatomy) , biology , psychology , computer science , artificial neural network , artificial intelligence , biochemistry , gene

Neuronal ensembles are coactive groups of neurons that may represent building blocks of cortical circuits. These ensembles could be formed by Hebbian plasticity, whereby synapses between coactive neurons are strengthened. Here we report that repetitive activation with two-photon optogenetics of neuronal populations from ensembles in the visual cortex of awake mice builds neuronal ensembles that recur spontaneously after being imprinted and do not disrupt preexisting ones. Moreover, imprinted ensembles can be recalled by single- cell stimulation and remain coactive on consecutive days. Our results demonstrate the persistent reconfiguration of cortical circuits by two-photon optogenetics into neuronal ensembles that can perform pattern completion.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research