Spatiotemporal coordination of stem cell commitment during epidermal homeostasis | Zendy

Panteleimon Rompolas | Zendy; Kailin R. Mesa | Zendy; Kyogo Kawaguchi | Zendy; SangBum Park | Zendy; David G. Gonzalez | Zendy; Samara Brown | Zendy; Jonathan Boucher | Zendy; Allon M. Klein | Zendy; Valentina Greco | Zendy

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Spatiotemporal coordination of stem cell commitment during epidermal homeostasis

Author(s) -

Panteleimon Rompolas,

Kailin R. Mesa,

Kyogo Kawaguchi,

SangBum Park,

David G. Gonzalez,

Samara Brown,

Jonathan Boucher,

Allon M. Klein,

Valentina Greco

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaf7012

Subject(s) - stem cell , epidermis (zoology) , microbiology and biotechnology , homeostasis , biology , cell fate determination , cell division , cell , adult stem cell , cellular differentiation , anatomy , genetics , gene , transcription factor

Tracking stem cell fate in time and space After injury and during homeostasis, tissues rely on the balance of cell loss and renewal. Rompolaset al. visualized individual stem cells over their lifetime in the epidermis of live mice. Tracking stem cells over multiple generations revealed that tissue homeostasis in the mouse epidermis is not maintained by asymmetric cell division as previously thought, but through the coordination of sibling cell fate and lifetimes. Furthermore, differentiating stem cells reused the existing spatial organization of the epidermis.Science , this issue p.1471

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