Comment on “Multiple repressive mechanisms in the hippocampus during memory formation” | Zendy

Rebecca S. Mathew | Zendy; Hillary Mullan | Zendy; Jan Krzysztof Blusztajn | Zendy; Maria K. Lehtinen | Zendy

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Comment on “Multiple repressive mechanisms in the hippocampus during memory formation”

Author(s) -

Rebecca S. Mathew,

Hillary Mullan,

Jan Krzysztof Blusztajn,

Maria K. Lehtinen

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaf1288

Subject(s) - hippocampus , hippocampal formation , choroid plexus , psychological repression , neuroscience , fear conditioning , psychology , gene expression , biology , central nervous system , gene , genetics , amygdala

Cho et al. (Reports, 2 October 2015, p. 82) report that gene repression after contextual fear conditioning regulates hippocampal memory formation. We observe low levels of expression for many of the top candidate genes in the hippocampus and robust expression in the choroid plexus, as well as repression at 4 hours after contextual fear conditioning, suggesting the inclusion of choroid plexus messenger RNAs in Cho et al. hippocampal samples.

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