Cross-species comparisons of host genetic associations with the microbiome | Zendy

Julia K. Goodrich | Zendy; Emily Davenport | Zendy; Jillian L. Waters | Zendy; Andrew G. Clark | Zendy; Ruth E. Ley | Zendy

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Cross-species comparisons of host genetic associations with the microbiome

Author(s) -

Julia K. Goodrich,

Emily Davenport,

Jillian L. Waters,

Andrew G. Clark,

Ruth E. Ley

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad9379

Subject(s) - microbiome , biology , coevolution , host (biology) , evolutionary biology , human microbiome , phenotype , genotype , genome , genetics , taxon , gene , ecology

Recent studies in human populations and mouse models reveal notable congruences in gut microbial taxa whose abundances are partly regulated by host genotype. Host genes associating with these taxa are related to diet sensing, metabolism, and immunity. These broad patterns are further validated in similar studies of nonmammalian microbiomes. The next generation of genome-wide association studies will expand the size of the data sets and refine the microbial phenotypes to fully capture these intriguing signatures of host-microbiome coevolution.

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