Design of structurally distinct proteins using strategies inspired by evolution | Zendy

Timothy M. Jacobs | Zendy; Benfeard Williams | Zendy; Tishan Williams | Zendy; Xiaohui Xu | Zendy; Alexander Eletsky | Zendy; Jasmin Federizon | Zendy; Thomas Szyperski | Zendy; Brian Kuhlman | Zendy

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Design of structurally distinct proteins using strategies inspired by evolution

Author(s) -

Timothy M. Jacobs,

Benfeard Williams,

Tishan Williams,

Xiaohui Xu,

Alexander Eletsky,

Jasmin Federizon,

Thomas Szyperski,

Brian Kuhlman

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad8036

Subject(s) - angstrom , protein design , high resolution , computational biology , protein structure , resolution (logic) , protein engineering , computer science , process (computing) , biology , nanotechnology , chemistry , crystallography , materials science , artificial intelligence , biochemistry , programming language , enzyme , remote sensing , geology

Building new proteins from the old Proteins are the workhorses of biology. Designing new, stable proteins with functions desirable in biotechnology or biomedicine remains challenging. Jacobset al. developed a computational method called SEWING that designs proteins using pieces of existing structures (see the Perspective by Netzer and Fleishman). The new proteins can contain structural features such as pockets or grooves that are required for function. The solved structures of two designed proteins agreed well with the design models. The method allows rapid design of a diverse set of structures that will facilitate functional design.Science , this issue p.687 ; see also p.657

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