Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation | Zendy

Alexander Rialdi | Zendy; Laura Campisi | Zendy; Nan Zhao | Zendy; Arvin Cesar Lagda | Zendy; Colette Pietzsch | Zendy; Jessica Ho | Zendy; Luis MartínezGil | Zendy; Romain Fenouil | Zendy; Xiaoting Chen | Zendy; Megan R. Edwards | Zendy; Giorgi Metreveli | Zendy; Stefan Jordan | Zendy; Zuleyma Peralta | Zendy; César MuñozFontela | Zendy; Nicole M. Bouvier | Zendy; Miriam Mérad | Zendy; Jian Jin | Zendy; Matthew T. Weirauch | Zendy; Sven Heinz | Zendy; Christopher Benner | Zendy; Harm van Bakel | Zendy; Christopher F. Basler | Zendy; Adolfo Garcı́a-Sastre | Zendy; Alexander Bukreyev | Zendy; Ivan Marazzi | Zendy

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Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

Author(s) -

Alexander Rialdi,

Laura Campisi,

Nan Zhao,

Arvin Cesar Lagda,

Colette Pietzsch,

Jessica Ho,

Luis MartínezGil,

Romain Fenouil,

Xiaoting Chen,

Megan R. Edwards,

Giorgi Metreveli,

Stefan Jordan,

Zuleyma Peralta,

César MuñozFontela,

Nicole M. Bouvier,

Miriam Mérad,

Jian Jin,

Matthew T. Weirauch,

Sven Heinz,

Christopher Benner,

Harm van Bakel,

Christopher F. Basler,

Adolfo Garcı́a-Sastre,

Alexander Bukreyev,

Ivan Marazzi

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad7993

Subject(s) - inflammation , topoisomerase , inflammatory response , gene , programmed cell death , chemistry , apoptosis , pharmacology , biology , immunology , enzyme , biochemistry

Unwinding DNA and unleasing inflammation Fighting infections often comes with collateral damage, which sometimes can be deadly. For instance, in septic shock, the overwhelming release of inflammatory mediators drives multi-organ failure. Rialdiet al. now report a potential new therapeutic target for controlling excessive inflammation: the DNA unwinding enzyme topoisomerase I (Top1) (see the Perspective by Pope and Medzhitov). Upon infection, Top1 specifically localizes to the promoters of pathogen-induced genes and promotes their transcription by helping to recruit RNA polymerase II. Pharmacological inhibition of Top1 in a therapeutic setting increased survival in several mouse models of severe microbially induced inflammation.Science , this issue p.10.1126/science.aad7993 ; see also p.1058

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