Functionalization of C(sp 3 )–H bonds using a transient directing group | Zendy

FangLin Zhang | Zendy; Kai Hong | Zendy; Tuanjie Li | Zendy; Hojoon Park | Zendy; JinQuan Yu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Functionalization of C(sp ³ )–H bonds using a transient directing group

Author(s) -

FangLin Zhang,

Kai Hong,

Tuanjie Li,

Hojoon Park,

JinQuan Yu

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad7893

Subject(s) - palladium , chemistry , catalysis , rhodium , amino acid , reactivity (psychology) , surface modification , inert , group (periodic table) , functional group , combinatorial chemistry , hydrogen bond , nitrogen , hydrogen , carbon fibers , organic chemistry , molecule , materials science , medicine , biochemistry , polymer , alternative medicine , pathology , composite number , composite material

Amino acids can lend palladium a hand Metals such as rhodium and palladium (Pd) are adept at activating otherwise inert carbon-hydrogen bonds toward useful reactivity. To get properly oriented, they often require some help from oxygen or nitrogen groups nearby. Appending and removing these directing groups, however, detracts from the efficiency of chemical synthesis. Zhanget al. show that amino acids can act as temporary directing groups in the Pd-catalyzed coupling of arenes with aldehydes or ketones. By reversibly binding to these latter substrates just long enough for the Pd catalysis to ensue, the amino acids eliminate the need for more laborious directing group manipulations.Science , this issue p.252

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research