Response to Comment on “A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme” | Zendy

Shinya Watanabe | Zendy; Craig L. Peterson | Zendy

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Response to Comment on “A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme”

Author(s) -

Shinya Watanabe,

Craig L. Peterson

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad6398

Subject(s) - chromatin remodeling , histone , acetylation , enzyme , chromatin , chemistry , substrate (aquarium) , microbiology and biotechnology , biochemistry , biology , gene , ecology

Wang et al. report a failure to reproduce our biochemical observation that the INO80C and SWR1C/SWR1/SWR-C chromatin remodeling enzymes catalyze replacement of nucleosomal H2A.Z with H2A when the substrate contains H3-K56Q. They point to technical problems with our dimer exchange assay. In response, we have recapitulated our findings using a mobility shift assay that was developed and employed by Wang and colleagues.

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