Complementation of mitochondrial electron transport chain by manipulation of the NAD + /NADH ratio | Zendy

Denis V. Titov | Zendy; Valentin Cracan | Zendy; Russell P. Goodman | Zendy; Jun Peng | Zendy; Ze Grabarek | Zendy; Vamsi K. Mootha | Zendy

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Complementation of mitochondrial electron transport chain by manipulation of the NAD ⁺ /NADH ratio

Author(s) -

Denis V. Titov,

Valentin Cracan,

Russell P. Goodman,

Jun Peng,

Ze Grabarek,

Vamsi K. Mootha

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad4017

Subject(s) - nad+ kinase , complementation , electron transport chain , chain (unit) , electron , chemistry , mitochondrion , biochemistry , physics , nuclear physics , enzyme , gene , phenotype , astronomy

Taking control of cellular NAD+ concentrationsCellular concentrations of the nicotinamide adenine dinucleotide (NAD+ ) are critical for proper metabolism and are often altered in aging and disease. To enable better understanding of these processes, Titovet al. altered the concentration of NAD+ in particular cellular compartments. They did this through expression of a bacterial enzyme targeted to specific compartments of human cells in culture. Their experiments emphasize the important role of the electron transport chain in redox transfer of electrons to NADH, rather than proton pumping, in mitochondrial pathogenesis.Science , this issue p.231

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