Open AccessOligodendrocyte precursors migrate along vasculature in the developing nervous system
Author(s) -
HuiHsin Tsai,
Jianqin Niu,
Roeben N. Munji,
Dimitrios Davalos,
Junlei Chang,
JJ H. Zhang,
AnChi Tien,
Calvin J. Kuo,
Jonah R. Chan,
Richard Daneman,
Stephen P.J. Fancy
Publication year - 2016
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.aad3839
Subject(s) - oligodendrocyte , microbiology and biotechnology , biology , progenitor cell , neuroscience , axon guidance , central nervous system , cell migration , precursor cell , mammalian brain , axon , cell , stem cell , myelin , genetics
Oligodendrocytes myelinate axons in the central nervous system and develop from oligodendrocyte precursor cells (OPCs) that must first migrate extensively during brain and spinal cord development. We show that OPCs require the vasculature as a physical substrate for migration. We observed that OPCs of the embryonic mouse brain and spinal cord, as well as the human cortex, emerge from progenitor domains and associate with the abluminal endothelial surface of nearby blood vessels. Migrating OPCs crawl along and jump between vessels. OPC migration in vivo was disrupted in mice with defective vascular architecture but was normal in mice lacking pericytes. Thus, physical interactions with the vascular endothelium are required for OPC migration. We identify Wnt-Cxcr4 (chemokine receptor 4) signaling in regulation of OPC-endothelial interactions and propose that this signaling coordinates OPC migration with differentiation.
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