The structure of the β-barrel assembly machinery complex | Zendy

Jeremy Bakelar | Zendy; Susan K. Buchanan | Zendy; Nicholas Noinaj | Zendy

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The structure of the β-barrel assembly machinery complex

Author(s) -

Jeremy Bakelar,

Susan K. Buchanan,

Nicholas Noinaj

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad3460

Subject(s) - barrel (horology) , bacterial outer membrane , membrane , biophysics , microbiology and biotechnology , chemistry , biology , crystallography , materials science , biochemistry , gene , composite material , escherichia coli

Going in with a BAM Integral membrane proteins in bacterial outer membranes play roles in nutrient import and infectivity. These proteins are folded into a barrel shape composed of β-strands and inserted into the outer membrane by the β-barrel assembly machinery (BAM) complex. Bakelaret al. determined the crystal structure of a four-component BAM subcomplex. The structure of a central β barrel in BAM changes in the presence of the accessory components to create a lateral opening that may be involved in how BAM inserts proteins into the outer membrane.Science , this issue p.180

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