Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure | Zendy

Neal D. Amin | Zendy; Ge Bai | Zendy; Jason R. Klug | Zendy; Dario Bonanomi | Zendy; Matthew Pankratz | Zendy; Wesley D. Gifford | Zendy; Christopher A. Hinckley | Zendy; Matthew J. Sternfeld | Zendy; Shawn P. Driscoll | Zendy; Bertha Dominguez | Zendy; KuoFen Lee | Zendy; Xin Jin | Zendy; Samuel L. Pfaff | Zendy

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Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure

Author(s) -

Neal D. Amin,

Ge Bai,

Jason R. Klug,

Dario Bonanomi,

Matthew Pankratz,

Wesley D. Gifford,

Christopher A. Hinckley,

Matthew J. Sternfeld,

Shawn P. Driscoll,

Bertha Dominguez,

KuoFen Lee,

Xin Jin,

Samuel L. Pfaff

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad2509

Subject(s) - motor neuron , microrna , neuroscience , biology , neuromuscular disease , disease , neuron , gene , neuromuscular junction , nervous system , medicine , genetics , spinal cord

The makings of motor neuron disease Developing motor neurons link the muscles to the central nervous system. Aminet al. found that microRNA-218 (miR-218) was expressed in developing motor neurons and repressed a wide network of genes whose expression typifies other sorts of neurons. Mice lacking miR-218 died at birth with symptoms characteristic of human motor neuron diseases.Science , this issue p.1525

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