An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels | Zendy

Bart L. Haagmans | Zendy; Judith M. A. van den Brand | Zendy; V. Stalin Raj | Zendy; Asisa Volz | Zendy; Peter Wohlsein | Zendy; Saskia L. Smits | Zendy; Debby Schipper | Zendy; Theo M. Bestebroer | Zendy; Nisreen M.A. Okba | Zendy; Robert Fux | Zendy; Albert Bensaïd | Zendy; David Solanes Foz | Zendy; Thijs Kuiken | Zendy; Wolfgang Baumgärtner | Zendy; Joaquím Segalés | Zendy; Gerd Sutter | Zendy; Albert D. M. E. Osterhaus | Zendy

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An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels

Author(s) -

Bart L. Haagmans,

Judith M. A. van den Brand,

V. Stalin Raj,

Asisa Volz,

Peter Wohlsein,

Saskia L. Smits,

Debby Schipper,

Theo M. Bestebroer,

Nisreen M.A. Okba,

Robert Fux,

Albert Bensaïd,

David Solanes Foz,

Thijs Kuiken,

Wolfgang Baumgärtner,

Joaquím Segalés,

Gerd Sutter,

Albert D. M. E. Osterhaus

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad1283

Subject(s) - middle east respiratory syndrome coronavirus , biology , virology , virus , transmission (telecommunications) , immunity , vaccination , coronavirus , veterinary medicine , immunology , covid-19 , medicine , immune system , disease , infectious disease (medical specialty) , electrical engineering , engineering , pathology

Middle East respiratory syndrome coronavirus (MERS-CoV) infections have led to an ongoing outbreak in humans, which was fueled by multiple zoonotic MERS-CoV introductions from dromedary camels. In addition to the implementation of hygiene measures to limit further camel-to-human and human-to-human transmissions, vaccine-mediated reduction of MERS-CoV spread from the animal reservoir may be envisaged. Here we show that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS-CoV spike protein confers mucosal immunity in dromedary camels. Compared with results for control animals, we observed a significant reduction of excreted infectious virus and viral RNA transcripts in vaccinated animals upon MERS-CoV challenge. Protection correlated with the presence of serum neutralizing antibodies to MERS-CoV. Induction of MVA-specific antibodies that cross-neutralize camelpox virus would also provide protection against camelpox.

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