T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 + T cells | Zendy

Giuseppina Arbore | Zendy; Erin E. West | Zendy; Rosanne Spolski | Zendy; Avril A. B. Robertson | Zendy; Andreas Klos | Zendy; Claudia Rheinheimer | Zendy; Pavel Dutow | Zendy; Trent M. Woodruff | Zendy; Zu Xi Yu | Zendy; Luke O'neill | Zendy; Rebecca C. Coll | Zendy; Alan Sher | Zendy; Warren J. Leonard | Zendy; Jörg Köhl | Zendy; Peter N. Monk | Zendy; Matthew A. Cooper | Zendy; Matthew Arno | Zendy; Behdad Afzali | Zendy; Helen J. Lachmann | Zendy; Andrew P. Cope | Zendy; Katrin D. Mayer-Barber | Zendy; Claudia Kemper | Zendy

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T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 ⁺ T cells

Author(s) -

Giuseppina Arbore,

Erin E. West,

Rosanne Spolski,

Avril A. B. Robertson,

Andreas Klos,

Claudia Rheinheimer,

Pavel Dutow,

Trent M. Woodruff,

Zu Xi Yu,

Luke O'neill,

Rebecca C. Coll,

Alan Sher,

Warren J. Leonard,

Jörg Köhl,

Peter N. Monk,

Matthew A. Cooper,

Matthew Arno,

Behdad Afzali,

Helen J. Lachmann,

Andrew P. Cope,

Katrin D. Mayer-Barber,

Claudia Kemper

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad1210

Subject(s) - complement (music) , immunity , inflammasome , chemistry , immune system , immunology , biology , virology , inflammation , biochemistry , gene , complementation , phenotype

Innate immune crosstalk in T cells The classical view of immune activation is that innate immune cells, such as macrophages and dendritic cells, recognize invading microbes and then alert adaptive immune cells, such as T cells, to respond. Arboreet al. now show that innate and adaptive immunity converge in human and mouse T cells. Activated T cells express components of the complement cascade, which in turn leads to the assembly of NLRP3 inflammasomes—both critical components of innate immunity that help hosts detect and eliminate microbes. In T cells, complement and inflammasomes work together to push T cells to differentiate into a specialized subset of T cells important for eliminating intracellular bacteria.Science , this issue p.10.1126/science.aad1210

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