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A special way to make T The genomes of all cell-based life consist of DNA. Blocking DNA synthesis is thus lethal, and if targeted selectively, its inhibition can provide cancer and antibiotic treatments. For example, the drug methotrexate interferes with the synthesis of thymidine, the base T in DNA. Mishaninaet al. found that the enzyme that carries out the last step of thymidine synthesis in several human pathogens, which cause tuberculosis, anthrax, and typhus, uses a previously undescribed mechanism. Knowing the mechanism may allow the development of specific inhibitors for this enzyme.Science , this issue p.507

An unprecedented mechanism of nucleotide methylation in organisms containing thyX