An unprecedented mechanism of nucleotide methylation in organisms containing thyX | Zendy

Tatiana V. Mishanina | Zendy; Liping Yu | Zendy; Kalani Karunaratne | Zendy; Dibyendu Mondal | Zendy; John M. Corcoran | Zendy; Michael Choi | Zendy; Am Kohen | Zendy

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An unprecedented mechanism of nucleotide methylation in organisms containing thyX

Author(s) -

Tatiana V. Mishanina,

Liping Yu,

Kalani Karunaratne,

Dibyendu Mondal,

John M. Corcoran,

Michael Choi,

Am Kohen

Publication year - 2016

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad0300

Subject(s) - nucleotide , mechanism (biology) , methylation , genetics , chemistry , dna methylation , biology , microbiology and biotechnology , physics , dna , gene , gene expression , quantum mechanics

A special way to make T The genomes of all cell-based life consist of DNA. Blocking DNA synthesis is thus lethal, and if targeted selectively, its inhibition can provide cancer and antibiotic treatments. For example, the drug methotrexate interferes with the synthesis of thymidine, the base T in DNA. Mishaninaet al. found that the enzyme that carries out the last step of thymidine synthesis in several human pathogens, which cause tuberculosis, anthrax, and typhus, uses a previously undescribed mechanism. Knowing the mechanism may allow the development of specific inhibitors for this enzyme.Science , this issue p.507

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