Fetal liver hematopoietic stem cell niches associate with portal vessels | Zendy

Jalal A. Khan | Zendy; Avital Mendelson | Zendy; Yuya Kunisaki | Zendy; Alexander Birbrair | Zendy; Yan Kou | Zendy; Anna Arnal Estape | Zendy; Sandra Pinho | Zendy; Paul Ciero | Zendy; Fumio Nakahara | Zendy; Avi Ma’ayan | Zendy; Aviv Bergman | Zendy; Miriam Mérad | Zendy; Paul S. Frenette | Zendy

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Fetal liver hematopoietic stem cell niches associate with portal vessels

Author(s) -

Jalal A. Khan,

Avital Mendelson,

Yuya Kunisaki,

Alexander Birbrair,

Yan Kou,

Anna Arnal Estape,

Sandra Pinho,

Paul Ciero,

Fumio Nakahara,

Avi Ma’ayan,

Aviv Bergman,

Miriam Mérad,

Paul S. Frenette

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aad0084

Subject(s) - stem cell , niche , haematopoiesis , biology , stem cell niche , nestin , bone marrow , fetus , hematopoietic stem cell , microbiology and biotechnology , pathology , immunology , progenitor cell , medicine , neural stem cell , genetics , pregnancy , ecology

Whereas the cellular basis of the hematopoietic stem cell (HSC) niche in the bone marrow has been characterized, the nature of the fetal liver niche is not yet elucidated. We show that Nestin(+)NG2(+) pericytes associate with portal vessels, forming a niche promoting HSC expansion. Nestin(+)NG2(+) cells and HSCs scale during development with the fractal branching patterns of portal vessels, tributaries of the umbilical vein. After closure of the umbilical inlet at birth, portal vessels undergo a transition from Neuropilin-1(+)Ephrin-B2(+) artery to EphB4(+) vein phenotype, associated with a loss of periportal Nestin(+)NG2(+) cells and emigration of HSCs away from portal vessels. These data support a model in which HSCs are titrated against a periportal vascular niche with a fractal-like organization enabled by placental circulation.

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