Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency | Zendy

Zheng Guo | Zendy; Benjamin Ohlstein | Zendy

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Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency

Author(s) -

Zheng Guo,

Benjamin Ohlstein

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aab0988

Subject(s) - notch signaling pathway , microbiology and biotechnology , biology , stem cell , cell division , notch proteins , asymmetric cell division , hes3 signaling axis , cell fate determination , signal transduction , cell , genetics , transcription factor , gene

Notch role in multipotency or cell fate MultipotentDrosophila intestinal stem cells (ISCs) generate either nutrient-absorbing enterocytes (ECs) or secretory enteroendocrine cells (EECs). Guo and Ohlstein investigated the role of Notch signaling in this process. They tracked ISC asymmetric divisions and found that EEC daughter cells, which have a low level of Notch, signal back to the ISC in order to keep it multipotent. However, during EC production, ISCs activate strong Notch signaling in daughters. Thus, Notch signaling functions in two directions to achieve stem cell multipotency.Science , this issue p.10.1126/science.aab0988

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