Comment on “Extreme electric fields power catalysis in the active site of ketosteroid isomerase” | Zendy

Deliang Chen | Zendy; Tor Savidge | Zendy

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Comment on “Extreme electric fields power catalysis in the active site of ketosteroid isomerase”

Author(s) -

Deliang Chen,

Tor Savidge

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aab0095

Subject(s) - ketosteroid , context (archaeology) , electric field , isomerase , catalysis , electric power , chemistry , field (mathematics) , power (physics) , physics , enzyme , thermodynamics , biochemistry , biology , quantum mechanics , paleontology , mathematics , pure mathematics

Fried et al. (Reports, 19 December 2014, p. 1510) demonstrate electric field–dependent acceleration of biological catalysis using ketosteroid isomerase as a prototypic example. These findings were not extended to aqueous solution because water by itself has field fluctuations that are too large and fast to provide a catalytic effect. Given physiological context, when water electrostatic interactions are considered, electric fields play a less important role in the catalysis.

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