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Transcription factor shape-shifts DNA Controlling when a gene is expressed or repressed is vital for cellular metabolism and development. InEscherichia coli , a copper-sensing transcription factor, CueR, can repress or activate expression when bound at exactly the same site in the gene promoter. Philipset al. used x-ray crystallography to show that CueR dramatically changes the topology of the DNA upon binding copper but does not affect protein-DNA contacts. The DNA shape change allows RNA polymerase to bind the promoter and transcribe the gene.Science , this issue p.877

Allosteric transcriptional regulation via changes in the overall topology of the core promoter