Allosteric transcriptional regulation via changes in the overall topology of the core promoter | Zendy

Steven J. Philips | Zendy; Mónica A. Canalizo-Hernández | Zendy; Ilyas Yildirim | Zendy; George C. Schatz | Zendy; Alfonso Mondragón | Zendy; Thomas V. O’Halloran | Zendy

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Allosteric transcriptional regulation via changes in the overall topology of the core promoter

Author(s) -

Steven J. Philips,

Mónica A. Canalizo-Hernández,

Ilyas Yildirim,

George C. Schatz,

Alfonso Mondragón,

Thomas V. O’Halloran

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaa9809

Subject(s) - repressor , transcription (linguistics) , allosteric regulation , promoter , dna , rna polymerase ii , rna polymerase , microbiology and biotechnology , biology , transcription factor , rna , genetics , gene , enzyme , biochemistry , gene expression , linguistics , philosophy

Transcription factor shape-shifts DNA Controlling when a gene is expressed or repressed is vital for cellular metabolism and development. InEscherichia coli , a copper-sensing transcription factor, CueR, can repress or activate expression when bound at exactly the same site in the gene promoter. Philipset al. used x-ray crystallography to show that CueR dramatically changes the topology of the DNA upon binding copper but does not affect protein-DNA contacts. The DNA shape change allows RNA polymerase to bind the promoter and transcribe the gene.Science , this issue p.877

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