Comment on “Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence” | Zendy

David H. Sherman | Zendy; Sachiko Tsukamoto | Zendy; Robert M. Williams | Zendy

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Comment on “Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence”

Author(s) -

David H. Sherman,

Sachiko Tsukamoto,

Robert M. Williams

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaa9349

Subject(s) - congener , biosynthesis , organism , stereochemistry , biology , chemistry , computational biology , biochemistry , genetics , organic chemistry , gene

Maet al . (Reports, 10 October 2014, p. 219) report asymmetric syntheses of sceptrin and massadine and, through a stereochemical reassignment, claim to “uncover enantiodivergence as a new biosynthetic paradigm for natural products.” We challenge and clarify this claim with relevant examples from the literature of this well-known phenomenon of enantiodivergent congener biosynthesis within the same producing organism.

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