Mus81 and converging forks limit the mutagenicity of replication fork breakage | Zendy

Ryan Mayle | Zendy; Ian M. Campbell | Zendy; Christine R. Beck | Zendy; Yang Yu | Zendy; Marenda A. Wilson | Zendy; Chad A. Shaw | Zendy; Lotte Bjergbæk | Zendy; James R. Lupski | Zendy; Grzegorz Ira | Zendy

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Mus81 and converging forks limit the mutagenicity of replication fork breakage

Author(s) -

Ryan Mayle,

Ian M. Campbell,

Christine R. Beck,

Yang Yu,

Marenda A. Wilson,

Chad A. Shaw,

Lotte Bjergbæk,

James R. Lupski,

Grzegorz Ira

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaa8391

Subject(s) - fork (system call) , breakage , replication (statistics) , limit (mathematics) , biology , genetics , computer science , virology , mathematics , mathematical analysis , world wide web , operating system

How to repair broken replication forks Double-strand breaks in DNA are extremely dangerous to the integrity of our genomes. Most arise from problems encountered by replication forks during duplication of genomic DNA. Break-induced replication is known to use an error-prone DNA polymerase to repair such damage. Mayleet al. show that cells limit error-prone DNA synthesis by preventing the DNA polymerase from inadvertently switching to a related sequence with an incorrect template. The repair of the break is achieved by using a structure-specific nuclease to prevent formation of a long single-stranded region.Science , this issue p.742

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