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Innate lymphoid cells keep gut T cells in check Trillions of bacteria inhabit our guts. So do many types of immune cells, including T cells, which might be expected to attack these bacteria. How, then, do our bodies manage to keep the peace? Working in mice, Hepworthet al. report one such mechanism. A population of immune cells, called innate lymphoid cells, directly killed CD4+ T cells that react to commensal gut microbes. Some of the specifics of this process parallel how the immune system keeps developing self-reactive T cells in check in the thymus. Furthermore, this peacekeeping process may be disrupted in children with inflammatory bowel disease.Science , this issue p.1031

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4 + T cells

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4 ⁺ T cells