Open AccessGroup 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4 + T cells
Author(s) -
Matthew R. Hepworth,
Thomas C. Fung,
Samuel H. Masur,
Judith R. Kelsen,
Fiona M. McConnell,
Juan Dubrot,
David R. Withers,
Stéphanie Hugues,
Michael A. Farrar,
Walter Reith,
Gérard Eberl,
Robert N. Baldassano,
Terri M. Laufer,
Charles O. Elson,
Gregory F. Sonnenberg
Publication year - 2015
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.aaa4812
Subject(s) - innate lymphoid cell , immunology , biology , autoimmunity , segmented filamentous bacteria , immune system , major histocompatibility complex , innate immune system , pathogenesis , t cell , inflammation , microbiology and biotechnology , sewage treatment , activated sludge , engineering , waste management
Innate lymphoid cells keep gut T cells in check Trillions of bacteria inhabit our guts. So do many types of immune cells, including T cells, which might be expected to attack these bacteria. How, then, do our bodies manage to keep the peace? Working in mice, Hepworthet al. report one such mechanism. A population of immune cells, called innate lymphoid cells, directly killed CD4+ T cells that react to commensal gut microbes. Some of the specifics of this process parallel how the immune system keeps developing self-reactive T cells in check in the thymus. Furthermore, this peacekeeping process may be disrupted in children with inflammatory bowel disease.Science , this issue p.1031
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