A virus that infects a hyperthermophile encapsidates A-form DNA | Zendy

Frank DiMaio | Zendy; Xiong Yu | Zendy; Elena Rensen | Zendy; Mart Krupovìč | Zendy; David Prangishvili | Zendy; Edward H. Egelman | Zendy

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A virus that infects a hyperthermophile encapsidates A-form DNA

Author(s) -

Frank DiMaio,

Xiong Yu,

Elena Rensen,

Mart Krupovìč,

David Prangishvili,

Edward H. Egelman

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaa4181

Subject(s) - capsid , hyperthermophile , prokaryote , dna , virus , biology , virology , sulfolobus , dna virus , archaea , genetics , genome , bacteria , gene

A viral DNA form that survives extremes The prokaryoteSulfolobus islandicus lives at extreme temperatures (∼80°C) and acidity (pH 3). It is infected by the rudivirus SIRV2. DiMaioet al. determined the structure of the SIRV2 virus using cryo–electron microscopy to understand how the virus survives these brutal conditions. Most DNA in nature assumes a B-form shape. The virion, on the other hand, contains highly unusual A-form DNA that may help it survive adverse conditions. The viral capsid protein forms an extended α-helical structure that wraps around the viral DNA, possibly stabilizing the A-form DNA.Science , this issue p.914

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