Systemic administration of epothilone B promotes axon regeneration after spinal cord injury | Zendy

Jörg Ruschel | Zendy; Farida Hellal | Zendy; Kevin C. Flynn | Zendy; Sebastián Dupraz | Zendy; David A. Elliott | Zendy; Andrea Tedeschi | Zendy; Margaret L. Bates | Zendy; Christopher Sliwinski | Zendy; Gary A. Brook | Zendy; Kristina Dobrindt | Zendy; Michael Peitz | Zendy; Oliver Brüstle | Zendy; Michael D. Norenberg | Zendy; Armin Blesch | Zendy; Norbert Weidner | Zendy; Mary Bartlett Bunge | Zendy; John L. Bixby | Zendy; Frank Bradke | Zendy

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Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

Author(s) -

Jörg Ruschel,

Farida Hellal,

Kevin C. Flynn,

Sebastián Dupraz,

David A. Elliott,

Andrea Tedeschi,

Margaret L. Bates,

Christopher Sliwinski,

Gary A. Brook,

Kristina Dobrindt,

Michael Peitz,

Oliver Brüstle,

Michael D. Norenberg,

Armin Blesch,

Norbert Weidner,

Mary Bartlett Bunge,

John L. Bixby,

Frank Bradke

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaa2958

Subject(s) - axon , spinal cord injury , regeneration (biology) , microtubule , spinal cord , central nervous system , neuroscience , medicine , pharmacology , biology , microbiology and biotechnology

Progress toward fixing a broken back? Axon regeneration after a spinal cord injury requires interference with neuronal mechanisms to promote axon extension and early suppression of scar formation. Microtubule stabilization could provide, in principle, a basis for such intervention. Ruschelet al. used animal models of spinal cord injury, time-lapse imaging in vivo, primary neuronal cultures, and behavioral studies to tackle this challenge (see the Perspective by Tran and Silver). They showed that epothilone B, a U.S. Food and Drug Administration–approved microtubule-stabilizing drug that can cross the blood-brain barrier, does promote functional axon regeneration, even after injury.Science , this issue p.347 ; see also p.285

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