A male-determining factor in the mosquito Aedes aegypti | Zendy

A. Brantley Hall | Zendy; S Basu | Zendy; Xiaofang Jiang | Zendy; Yumin Qi | Zendy; Vladimir A. Timoshevskiy | Zendy; James K. Biedler | Zendy; Maria V. Sharakhova | Zendy; Rubayet Elahi | Zendy; Michelle A. E. Anderson | Zendy; XiaoGuang Chen | Zendy; Igor V. Sharakhov | Zendy; Zach N. Adelman | Zendy; Zhijian Tu | Zendy

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A male-determining factor in the mosquito Aedes aegypti

Author(s) -

A. Brantley Hall,

S Basu,

Xiaofang Jiang,

Yumin Qi,

Vladimir A. Timoshevskiy,

James K. Biedler,

Maria V. Sharakhova,

Rubayet Elahi,

Michelle A. E. Anderson,

XiaoGuang Chen,

Igor V. Sharakhov,

Zach N. Adelman,

Zhijian Tu

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaa2850

Subject(s) - aedes aegypti , biology , doublesex , genetics , locus (genetics) , crispr , gene , larva , botany , rna splicing , rna

Manipulating M factor alters mosquito sex Female mosquitoes feed on blood and in so doing transmit pathogens to millions annually. Although the molecular mechanism for determining sex in many animals is known, the specific factors in mosquitoes have been elusive. This is because sex determination in insects involves a section of the genome that is highly repetitive. Hallet al. now identify a male-determining factor (M factor) inAedes aegypti. Manipulation of the M factor produced sex-change phenotypes. Knocking out the geneNix resulted in feminized males, and ectopic expression gave masculinized females. These findings should help to advance strategies for converting female mosquitoes into nonbiting males.Science , this issue p.1268

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