A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging | Zendy

Mary Mohrin | Zendy; Jiyung Shin | Zendy; Yufei Liu | Zendy; Katharine Brown | Zendy; Hanzhi Luo | Zendy; Yannan Xi | Zendy; Cole M. Haynes | Zendy; Danica Chen | Zendy

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A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

Author(s) -

Mary Mohrin,

Jiyung Shin,

Yufei Liu,

Katharine Brown,

Hanzhi Luo,

Yannan Xi,

Cole M. Haynes,

Danica Chen

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaa2361

Subject(s) - microbiology and biotechnology , stem cell , haematopoiesis , proteostasis , biology , hematopoietic stem cell , unfolded protein response , mitochondrion , nrf1 , regenerative medicine , mitochondrial biogenesis , endoplasmic reticulum

Keeping stem cells in tip top condition Stem cells are important in the maintenance and growth of tissues. For the health of the organism as a whole, it is important that only healthy stem cells be used. Mohrinet al. elucidated a regulatory branch of the mitochondrial unfolded protein response that is coupled to cellular energy metabolism and proliferation in stem cells (see the Perspective by Ocampo and Belmonte). Mitochondrial protein folding stress triggered a metabolic checkpoint that regulates the cell cycle. Deregulation of this pathway interfered with stem cell quiescence and compromised regenerative function.Science , this issue p.1374 ; see also p.1319

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