Detecting Protein Function and Protein-Protein Interactions from Genome Sequences | Zendy

Edward M. Marcotte | Zendy; Matteo Pellegrini | Zendy; Ho Leung Ng | Zendy; Danny W. Rice | Zendy; Todd O. Yeates | Zendy; David Eisenberg | Zendy

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Detecting Protein Function and Protein-Protein Interactions from Genome Sequences

Author(s) -

Edward M. Marcotte,

Matteo Pellegrini,

Ho Leung Ng,

Danny W. Rice,

Todd O. Yeates,

David Eisenberg

Publication year - 1999

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.285.5428.751

Subject(s) - genome , computational biology , biology , protein–protein interaction , function (biology) , genetics , protein function , homologous chromosome , yeast , gene

A computational method is proposed for inferring protein interactions from genome sequences on the basis of the observation that some pairs of interacting proteins have homologs in another organism fused into a single protein chain. Searching sequences from many genomes revealed 6809 such putative protein-protein interactions in Escherichia coli and 45,502 in yeast. Many members of these pairs were confirmed as functionally related; computational filtering further enriches for interactions. Some proteins have links to several other proteins; these coupled links appear to represent functional interactions such as complexes or pathways. Experimentally confirmed interacting pairs are documented in a Database of Interacting Proteins.

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