Evolutionary changes in promoter and enhancer activity during human corticogenesis | Zendy

Steven K. Reilly | Zendy; Jun Yin | Zendy; Albert E. Ayoub | Zendy; Deena Emera | Zendy; Jing Leng | Zendy; Justin Cotney | Zendy; Richard Sarro | Zendy; Pasko Rakić | Zendy; James P. Noonan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Evolutionary changes in promoter and enhancer activity during human corticogenesis

Author(s) -

Steven K. Reilly,

Jun Yin,

Albert E. Ayoub,

Deena Emera,

Jing Leng,

Justin Cotney,

Richard Sarro,

Pasko Rakić,

James P. Noonan

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1260943

Subject(s) - corticogenesis , enhancer , macaque , epigenetics , biology , human brain , epigenesis , neuroscience , gene , embryonic stem cell , rhesus macaque , gene expression , regulation of gene expression , evolutionary biology , genetics , dna methylation

Of mice, men, and macaque brains The human brain represents a unique evolutionary trajectory. To better understand how the human brain came to be, Reillyet al. sought to identify changes in gene expression between mice, macaques, and humans. They compared epigenetic marks in the embryonic cortex, which revealed changes in gene regulation in biological pathways associated with cortical development.Science , this issue p.1155

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research