Open AccessAntimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation
Author(s) -
Thomas W. Cullen,
Whitman B. Schofield,
Natasha A. Barry,
Emily E. Putnam,
Ethan A. Rundell,
M. Stephen Trent,
Patrick H. Degnan,
Carmen J. Booth,
Hongbing Yu,
Andrew L. Goodman
Publication year - 2015
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.1260580
Subject(s) - biology , microbiology and biotechnology , immune system , bacteroides thetaiotaomicron , bacteria , commensalism , microbiome , antimicrobial peptides , lipopolysaccharide , inflammation , colonisation resistance , salmonella , gut flora , antimicrobial , bacteroidetes , host (biology) , immunology , bacteroides , colonization , ecology , genetics , 16s ribosomal rna
Gut microbes resist inflammation It is vital to human well-being that our gut microbiota can be distinguished from harmful, but often very similar, organisms. Cullenet al. begin to analyze how one dominant symbiont,Bacteroidetes thetaiotaomicron , does this. Our guts release potent antimicrobial peptides when we become infected with pathogenic bacteria such as salmonella, but these symbionts make an outer lipopolysaccharide coat that differs from those of pathogens by only one phosphate molecule. Enzymatic removal of this group is enough to confer resistance to the host's immune response and allow the symbionts to escape damage.Science , this issue p.170
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