Dynamic profiling of the protein life cycle in response to pathogens | Zendy

Marko Jovanović | Zendy; Michael S. Rooney | Zendy; Philipp Mertins | Zendy; Dariusz Przybylski | Zendy; Nicolas Chevrier | Zendy; Rahul Satija | Zendy; Edwin H. Rodriguez | Zendy; Alexander P. Fields | Zendy; Schraga Schwartz | Zendy; Raktima Raychowdhury | Zendy; Maxwell R. Mumbach | Zendy; Thomas Eisenhaure | Zendy; Michal Rabani | Zendy; Dave Gennert | Zendy; Diana Lu | Zendy; Toni Delorey | Zendy; Jonathan S. Weissman | Zendy; Steven A. Carr | Zendy; Nir Hacohen | Zendy; Aviv Regev | Zendy

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Dynamic profiling of the protein life cycle in response to pathogens

Author(s) -

Marko Jovanović,

Michael S. Rooney,

Philipp Mertins,

Dariusz Przybylski,

Nicolas Chevrier,

Rahul Satija,

Edwin H. Rodriguez,

Alexander P. Fields,

Schraga Schwartz,

Raktima Raychowdhury,

Maxwell R. Mumbach,

Thomas Eisenhaure,

Michal Rabani,

Dave Gennert,

Diana Lu,

Toni Delorey,

Jonathan S. Weissman,

Steven A. Carr,

Nir Hacohen,

Aviv Regev

Publication year - 2015

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.1259038

Subject(s) - biology , gene expression , rna , gene , housekeeping gene , immune system , regulation of gene expression , genome , protein biosynthesis , microbiology and biotechnology , computational biology , genetics

Protein expression is regulated by production and degradation of mRNAs and proteins, but their specific relationships remain unknown. We combine measurements of protein production and degradation and mRNA dynamics to build a quantitative genomic model of the differential regulation of gene expression in LPS-stimulated mouse dendritic cells. Changes in mRNAabundance play a dominant role in determining most dynamic fold changes in protein levels. Conversely, the preexisting proteome of proteins performing basic cellular functions is remodeled primarily through changes in protein production or degradation, accounting for over half of theabsolute change in protein molecules in the cell. Thus, the proteome is regulated by transcriptional induction of novel cellular functions and remodeling of preexisting functions through the protein life cycle.National Human Genome Research Institute (U.S.) (Center for Excellence in Genomics Science P50 HG006193)Broad Institute of MIT and HarvardNational Institutes of Health (U.S.) (Pioneer Award)Howard Hughes Medical InstituteNational Institutes of Health (U.S.) (Training Program in Bioinformatics and Integrative Genomics Training Grant

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