Open AccessProliferation of cells with HIV integrated into cancer genes contributes to persistent infection
Author(s) -
Thor A. Wagner,
Sherry McLaughlin,
Kavita S. Garg,
Charles Y. K. Cheung,
Brendan B. Larsen,
Sheila Styrchak,
Hannah C. Huang,
Paul T. Edlefsen,
James I. Mullins,
Lisa M. Frenkel
Publication year - 2014
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.1256304
Subject(s) - virology , biology , gene , persistence (discontinuity) , viral replication , virus , human immunodeficiency virus (hiv) , cell growth , cancer , genetics , geotechnical engineering , engineering
A not-so-random integration for HIV Even in the face of a cocktail of antiretroviral drugs, HIV manages to hang on. It does so by integrating its own genome into those of host cells, where it persists in a latent state. To better understand this process, Wagneret al. determined the sites where HIV integrated into three HIV-infected patients treated with antiretroviral drugs for more than a decade. They found an over-representation of sites where HIV integrated into genes associated with cancer and cell proliferation. Also, multiple cells in the same individual harbored the same integration sites. This suggests that integration into specific genes may drive cell proliferation and viral persistence.Science , this issue p.570
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom